The resurgence in time-of-flight mass spectrometry
β Scribed by D. Price
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 724 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0165-9936
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In the 1990s time-of-flight mass spectrometry (TOFMS) has reestablished itself as a mainstream technique in mass spectrometry. There have been several developments which have contributed to this. The development of the technique of matrix-assisted laser desorption/ionization (MALDI), a pulsed ioniza
Multi-photon excitation in a time-of-flight mass spectrometer (TOF-MS) is shown to lead to threshold ions with defined internal energy. A powerful technique for the production of threshold ions is based on the excitation of high long-lived Rydberg states embedded in the ionization continuum. The Ryd
The principles and applications of time-of-Β―ight mass spectrometry involving instruments with independent (orthogonal) axes for ion generation and mass analysis are reviewed. This approach, generally referred to as orthogonal acceleration time-of-Β―ight mass spectrometry, has proved particularly adva
## Abstract This paper focuses on development of timeβofβflight (TOF) mass spectrometry in response to the invention of matrixβassisted laser desorption/ionization (MALDI). Before this breakthrough ionization technique for nonvolatile molecules, TOF was generally considered as a useful tool for exo