✦ LIBER ✦

Orthogonal acceleration time-of-flight mass spectrometry

✍ Scribed by M. Guilhaus; D. Selby; V. Mlynski

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 918 KB
Volume: 19
Category: Article
ISSN: 0277-7037
DOI: 10.1002/(sici)1098-2787(2000)19:2<65::aid-mas1>3.0.co;2-e

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✦ Synopsis

The principles and applications of time-of-¯ight mass spectrometry involving instruments with independent (orthogonal) axes for ion generation and mass analysis are reviewed. This approach, generally referred to as orthogonal acceleration time-of-¯ight mass spectrometry, has proved particularly advantageous for the combination of continuous ionization sources with time-of-¯ight mass spectrometry. The history of the technique is brie¯y discussed along with the instrumental principles pertaining to all the stages of the instrumentation from ion source to detector. The applications of commercial and customized instruments are discussed for several ionization methods including electrospray, matrix assisted laser desorption/ionization, electron ionization, and plasma ionization.

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