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The repair of DNA damage: Recent developments and new insights

✍ Scribed by Friedberg, E.C. ;Bonura, T. ;Love, J.D. ;McMillan, S. ;Radany, E.H. ;Schultz, R.A.

Publisher
Wiley (John Wiley & Sons)
Year
1981
Tongue
English
Weight
771 KB
Volume
16
Category
Article
ISSN
0275-3723

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✦ Synopsis

Abstract

This brief review presents the salient features of new developments in the enzymatic repair of base damage to DNA. DNA glycosylases and apurinic/ apyrimidinic (AP) endonucleases are reviewed and evidence is presented that in at least two prokaryote systems incision of UV‐irradiated DNA occurs by the sequential action of these two classes of enzymes. In contradistinction, the uvrA, uvrB, and uvrC gene products of E coli appear to function as a multiprotein complex that catalyzes hydrolysis of phosphodiester bonds in damaged DNA directly. The inducible rapid repair of O^6^‐ methylguanine in E coli is also reviewed.

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