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DNA damage detection and repair, and the involvement of epigenetic states

✍ Scribed by Sahar Bassal; Assam El-Osta

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 192 KB
Volume: 25
Category: Article
ISSN: 1059-7794
DOI: 10.1002/humu.20130

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✦ Synopsis

Chromatin is a highly dynamic structure that acts alternately as a substrate and a template in a number of critical biological processes. Modification of chromatin is pertinent and is responsible for a number of nuclear processes, including DNA repair, replication, transcription, and recombination. The purpose of this review is to discuss specific interactions between chromatin remodeling, DNA repair, and transcription. These areas are demonstrated to share commonality, particularly with a number of key molecules that appear to have roles in a number of pathways. The implications of pathway cross-over and communication form a seamless continuation of genomic integrity and stability.

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