## Communicated by Jurgen Horst Autosomal recessive polycystic kidney disease (ARPKD) is an important cause of childhood renal-and liverrelated morbidity and mortality. The clinical spectrum is widely variable. About 30 to 50% of affected individuals die in the neonatal period, while others survive
The renin-angiotensin system and hypertension in autosomal recessive polycystic kidney disease
β Scribed by Miwa Goto; Nita Hoxha; Rania Osman; Katherine MacRae Dell
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 443 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0931-041X
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The autosomal dominant form of polycystic kidney disease (ADPKD) has been linked to the alpha-globin gene locus on 16p. Linkage studies between the autosomal recessive type (ARPKD) and the 3' HVR of the alpha-globin gene cluster showed that the ARPKD and ADPKD are not allelic.
## Communicated by A. Jamie Cuticchia Autosomal recessive polycystic kidney disease (ARPKD) is an important cause of childhood renal-and liverrelated morbidity and mortality with variable disease expression. While most cases manifest peri-/neonatally with a high mortality rate in the first month of