Pathways of apoptosis in human autosomal recessive and autosomal dominant polycystic kidney diseases
β Scribed by Beatrice Goilav; Lisa M. Satlin; Patricia D. Wilson
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 507 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0931-041X
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π SIMILAR VOLUMES
Linkage analysis has been carried out in 11 kindreds with autosomal recessive polycystic kidney disease (ARPKD) using the genetic marker 3'HVR, closely linked (theta = 0.05) to the gene of the autosomal dominant type. Close linkage (theta less than or equal to 0.20) between the locus of the marker a
The autosomal dominant form of polycystic kidney disease (ADPKD) has been linked to the alpha-globin gene locus on 16p. Linkage studies between the autosomal recessive type (ARPKD) and the 3' HVR of the alpha-globin gene cluster showed that the ARPKD and ADPKD are not allelic.
The results of classical segregation analysis on 159 families with polycystic kidney disease (PKD) are presented. It had been previously estimated that about 95% of autosomal dominant PDK (ADPKD) families have PKD 1, the gene localized to chromosome 16p. The main purpose of the study was to determin