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Autosomal recessive and dominant forms of polycystic kidney disease are not allelic

✍ Scribed by Brunhilde Wirth; K. Zerres; M. Fischbach; Dorothea Claus; H. P. H. Neumann; T. Lennert; J. Brodehl; M. Neugebauer; D. E. Müller-Wiefel; J. Geisert; A. Gal

Publisher
Springer
Year
1987
Tongue
English
Weight
169 KB
Volume
77
Category
Article
ISSN
0340-6717

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✦ Synopsis

Linkage analysis has been carried out in 11 kindreds with autosomal recessive polycystic kidney disease (ARPKD) using the genetic marker 3'HVR, closely linked (theta = 0.05) to the gene of the autosomal dominant type. Close linkage (theta less than or equal to 0.20) between the locus of the marker and that of ARPKD can be excluded. These data strongly suggest that the loci for the autosomal recessive and dominant forms of polycystic kidney disease are not allelic.

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