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The relative importance of N-oxidation and N-demethylation in the metabolism of trimethylamine in man

✍ Scribed by Makram Al-Waiz; Stephen C. Mitchell; Jeffrey R. Idle; Robert L. Smith


Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
198 KB
Volume
43
Category
Article
ISSN
0300-483X

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p-hydroxymethamphetamine (OHMAP) is one of the major metabolites of the widely abused drug methamphetamine (MAP). The demethylation of OHMAP to phydroxyamphetamine (OHAP) has been shown in vitro but has never been reported in vivo. The disposition kinetics as well as the metabolism of OHMAP was inve

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We report a method based upon fast atom bombardment mass spectrometry (FAB-MS) and stable isotope dilution techniques for the measurement of urinary trimethylamine (TMA) and trimethylamine N-oxide (TMAOx). TMA is extracted from urine that was spiked with 15 N-labeled TMA. The extracted TMA isotopome