I n the recent paper by R. K. S. Lim and the writer ( '26) 011 secretory changes in the cells of the gastric glands, the authors endeavored to determine, in cases well controlled by observation of the secretory rate in animals provided with a gastric fistula o r a Pawlow pouch, the coincident changes in the cytology of the glandular components. The animals in these experiments were kept for twenty-four hours without food, then a control observation of basal secretion was made and a piece of mucous membrane snipped out for control. The glands were stimulated to activity by injections of histamine acid phosphate or by a meal, and the secretion watched throughout the entire experimental period. Pieces of mucous membrane were removed for histological preparation and study at intervals of four hours.
In this study it was found that the peptic cells of the resting phase, when full of zymogen granules, contained only dot-like mitochondria chiefly restricted to the peripheral re- gion of the cell, while the mitochondria in the cell which has discharged its zymogen granules were in a network throughout the entire cytoplasm. Furthermore, as the mitochondria develop, they exhibit varicosities or even swellings at their