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The relation of cyclic AMP levels to phagocytosis and enzyme release in acute inflammation in vivo

✍ Scribed by D. A. Deporter; P. A. Dieppe; M. Glatt; D. A. Willoughby

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
856 KB
Volume
121
Category
Article
ISSN
0022-3417

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✦ Synopsis

The effect of altering endogenous leucocyte cyclic AMP levels on phagocytosis and lysosomal enzyme release was studied in vivo. Acute pleural exudates were produced in rats using either calcium pyrophosphate dihydrate crystals or rat serum. Despite marked increases in leucocyte cyclic AMP concentration produced by injection of dibutyryl cyclic AMP and theophylline, there was no reduction in crystal phagocytosis or in enzyme discharge.

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