✦ LIBER ✦

Cyclic amp and the mechanism of leucocyte lysosomal enzyme release during an immediate hypersensitivity reaction in vivo

✍ Scribed by D. A. Deporter

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 449 KB
Volume: 123
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711230302

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✦ Synopsis

The pleural cavity of rats was used to study the effect of altering leucocyte cyclic AMP content on the release of B-glucuronidase activity during an immediate hypersensitivity reaction. The effect on intravenous colchicine was also studied. Despite an increase of 135 to 235% in leucocyte cyclic AMP content no decrease in B-glucuronidase release was observed. Similarly, colchicine had no effect on enzyme release. It was concluded that the cyclic nucleotides and leucocyte microtubules may have no significant role to play in the release of lysosomal enzymes during acute inflammation in vivo.

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Effects of modification of intracellular

Effects of modification of intracellular cyclic AMP levels on the immediate hypersensitivity reaction in vivo

✍ D. A. Deporter; F. Capasso; D. A. Willoughby 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 763 KB

Experiments were performed to study the effects of agents that elevate endogenous cyclic AMP levels on the progression of a reverse passive Arthus reaction in the pleural cavity of rats. Three hours after the onset of the reaction a marked reduction in histamine release was observed which correlated