๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Effects of modification of intracellular cyclic AMP levels on the immediate hypersensitivity reaction in vivo

โœ Scribed by D. A. Deporter; F. Capasso; D. A. Willoughby

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
763 KB
Volume
119
Category
Article
ISSN
0022-3417

No coin nor oath required. For personal study only.

โœฆ Synopsis

Experiments were performed to study the effects of agents that elevate endogenous cyclic AMP levels on the progression of a reverse passive Arthus reaction in the pleural cavity of rats. Three hours after the onset of the reaction a marked reduction in histamine release was observed which correlated well with increases in cellular cyclic AMP concentration. The results at 6 hr suggested a relationship between cyclic AMP and leucocyte PGE, the latter being reduced dramatically both in the cells and in the fluid exudate by agents that elevate cyclic AMP. It was concluded that cyclic AMP may play an important regulatory role in vivo in the release of inflammatory mediators from leucocytes.

๐Ÿ“œ SIMILAR VOLUMES

Cyclic amp and the mechanism of leucocyt
Cyclic amp and the mechanism of leucocyte lysosomal enzyme release during an immediate hypersensitivity reaction in vivo
โœ D. A. Deporter ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 449 KB

The pleural cavity of rats was used to study the effect of altering leucocyte cyclic AMP content on the release of B-glucuronidase activity during an immediate hypersensitivity reaction. The effect on intravenous colchicine was also studied. Despite an increase of 135 to 235% in leucocyte cyclic AMP

In vitro effect of a thymic epithelial c
In vitro effect of a thymic epithelial culture supernate or thymosin fraction 5 on rabbit platelet aggregation and intracellular cyclic AMP levels
โœ Shuichi Hashimoto; Yukie Itoh; Akiko Kawaguchi; Yoshio Mizuno; Matuo Muraoka; Ma ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 926 KB

## 760 (M. I), Japan Supernates of thymic epithelial cell culture (STEC) strongly inhibit aggregation induced by addition of adenosine diphosphate (ADP: 1 pM) or thrombin (0.5 unit per ml) to washed platelet suspensions and accelerated t h e restoration from ADP-triggered aggregation. At the same t