✦ LIBER ✦

The regulation of self-reactive B cells

✍ Scribed by Richard J Cornall; Christopher C Goodnow; Jason G Cyster

Book ID: 103973153
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 892 KB
Volume: 7
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(95)80052-2

No coin nor oath required. For personal study only.

✦ Synopsis

Self-reactive B cells are eliminated in a series of checkpoints that are triggered by antigen binding. Recent reports have shown that in addition to the processes of elimination at the immature B-cell stage, B-cell anergy and regulation of T-cell help, self-reactive cells are also controlled by follicular competition, Fas-mediated elimination by T cells and censoring in the germinal centres. Each checkpoint operates at a threshold that reflects the need to maintain immune diversity at the same time as suppressing autoimmune disease. Analysis of the motheaten mutation has given a direct demonstration of how such thresholds can be modulated by genetic effects.

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