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Fate of self-reactive B cells

✍ Scribed by DeFranco, Anthony L.

Book ID
109756207
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
288 KB
Volume
334
Category
Article
ISSN
0028-0836

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Self-reactive B cells are eliminated in a series of checkpoints that are triggered by antigen binding. Recent reports have shown that in addition to the processes of elimination at the immature B-cell stage, B-cell anergy and regulation of T-cell help, self-reactive cells are also controlled by foll

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We have previously demonstrated that antigen-specific T cell help can rescue mature Ig transgenic (Tg) hen egg lysozyme (HEL)-specific B cells from tolerance induction upon transfer into soluble HEL-expressing Tg hosts. Here we extend these findings by showing that T cell help could also rescue both