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CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

✍ Scribed by Rathmell, Jeffrey C.; Cooke, Michael P.; Ho, William Y.; Grein, Jeff; Townsend, Sarah E.; Davis, Mark M.; Goodnow, Christopher C.


Book ID
109793494
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
879 KB
Volume
376
Category
Article
ISSN
0028-0836

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Serum from normal individuals contains substantial amounts of natural antibodies (NA) capable of recognizing self antigens. However, the physiological implications of this autoreactivity remain unclear. We have examined the role of self-reactive NA and complement in mediating the uptake of human thy