Self-Reactive CD4+T Cells and B Cells in the Blood in Health and Autoimmune Disease: Increased Frequency of Thyroglobulin-Reactive Cells in Graves’ Disease
✍ Scribed by CLAUS H. NIELSEN; ANE CHRISTINE MOELLER; LASZLO HEGEDÜS; KLAUS BENDTZEN; R. GRAHAM Q. LESLIE
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 403 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0271-9142
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Serum from normal individuals contains substantial amounts of natural antibodies (NA) capable of recognizing self antigens. However, the physiological implications of this autoreactivity remain unclear. We have examined the role of self-reactive NA and complement in mediating the uptake of human thy
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