Association of the T-cell regulatory geneCTLA4with Graves’ disease and autoimmune thyroid disease in the Japanese

Regulatory CD4+ T cells and the control

Regulatory CD4+ T cells and the control of autoimmune disease

✍ David C Wraith; Kirsty S Nicolson; Nathaniel T Whitley 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 232 KB

The immune system is a delicately balanced network of interacting cells. In recent years, the concept of immune regulation/suppression has been firmly established, and both natural and induced regulatory cells play vital roles in protection from autoimmune disease. Recent work has revealed the diver

The Epigenetics of Autoimmune Diseases (

The Epigenetics of Autoimmune Diseases (Zouali/The Epigenetics of Autoimmune Diseases) || Epigenetic Modifications Associated with T Cell Tolerance

✍ Zouali, Moncef 📂 Article 📅 2009 🏛 John Wiley & Sons, Ltd 🌐 English ⚖ 292 KB 👁 1 views

The vertebrate immune system has evolved to protect against invasive pathogens, but with this adaptation comes the risk of autoimmunity, the recognition and destruction of self tissues by cells of the immune system. To avoid this problem the system has evolved active mechanisms by which tolerance is

The Epigenetics of Autoimmune Diseases (

The Epigenetics of Autoimmune Diseases (Zouali/The Epigenetics of Autoimmune Diseases) || Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells

✍ Zouali, Moncef 📂 Article 📅 2009 🏛 John Wiley & Sons, Ltd 🌐 English ⚖ 844 KB

The Role Of Epigenetic Mechanisms In Autoimmune Disease Is Only Now Starting To Become Clear. Understanding These Mechanisms, Their Effect On Cellular Function And The Role Of Environmental Factors Is Vital To Determining How To Manage These Often Debilitating And Fatal Diseases. drawing On The Res

Self-Reactive CD4+T Cells and B Cells in

Self-Reactive CD4+T Cells and B Cells in the Blood in Health and Autoimmune Disease: Increased Frequency of Thyroglobulin-Reactive Cells in Graves’ Disease

✍ CLAUS H. NIELSEN; ANE CHRISTINE MOELLER; LASZLO HEGEDÜS; KLAUS BENDTZEN; R. GRAH 📂 Article 📅 2006 🏛 Springer 🌐 English ⚖ 403 KB

The Epigenetics of Autoimmune Diseases (

The Epigenetics of Autoimmune Diseases (Zouali/The Epigenetics of Autoimmune Diseases) || Regulation of T Cell Anergy and Escape from Regulatory T Cell Suppression by Cbl-b

✍ Zouali, Moncef 📂 Article 📅 2009 🏛 John Wiley & Sons, Ltd 🌐 English ⚖ 373 KB 👁 1 views

The Role Of Epigenetic Mechanisms In Autoimmune Disease Is Only Now Starting To Become Clear. Understanding These Mechanisms, Their Effect On Cellular Function And The Role Of Environmental Factors Is Vital To Determining How To Manage These Often Debilitating And Fatal Diseases. drawing On The Res

Vigorous activation of monocytes in juve

Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells

✍ Maria Serena Longhi; Ragai R. Mitry; Marianne Samyn; Astrid Scalori; Munther J. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB

Interface hepatitis, the histological lesion typical of autoimmune hepatitis (AIH), is composed of CD4 and CD8 T lymphocytes and of innate immunity cells, particularly monocytes. Studies in AIH have focused on autoreactive CD4 and CD8 T cells and impairment of CD4؉CD25؉ regulatory T cells (T-regs),