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The regulation of RNA synthesis in yeast I: Starvation experiments

โœ Scribed by Oliver, Stephen G. ;McLaughlin, Calvin S.

Publisher
Springer
Year
1977
Tongue
English
Weight
765 KB
Volume
154
Category
Article
ISSN
0026-8925

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โœฆ Synopsis

The synthesis of tRNA in yeast is shown to be under separate control to that of rRNA during amino acid and nitrogen starvation. Inhibitors of the elongation and termination steps of protein synthesis were found to stimulate the synthesis of tRNA in starved yeast cells. This effect appeared to be due to the "trickle-charging" of tRNA. Two inhibitors of early steps in the initiation of protein synthesis were found to be unable to stimulate RNA synthesis in starved cells. It is proposed that yeast tRNA synthesis is under autoregulatory control and that the level of tRNA charging and the mRNA-ribosome complex are important components of this control system.

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Regulation of RNA synthesis in yeast III
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