The regulating effects of protein kinase C on the tone of guinea-pig trachea and human lobus bronchi
β Scribed by Xiansheng, Liu ;Yongjian, Xu ;Zhenxiang, Zhang ;Wang, Ni
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 318 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0257-716X
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In the course of examining the role of protein kinase C in signal transduction in dispersed chief cells from guinea pig stomach, we observed that phorbol esters in hi bit prostaglandin (PG)-st irnu I ated increases i n cyclic adenosine rnonophosphate (CAMP). Phorbol 12-myristate 13-acetate (PMA), an
ANF, ANF7-28 and atriopeptins (AP1, AP2 and AP3) (10(-11) to 3 x 10(-7) M) induce a relaxant response on the guinea-pig isolated trachea, which is partially potentiated by the enkephalinase inhibitor thiorphan 10(-5) M but is unmodified by epithelium removal. Conversely, these drugs were found to be