The effect of the enantiomers of formoterol on inherent and induced tone in guinea-pig trachea and human bronchus
✍ Scribed by D. Schmidt; B.-L. Källström; B. Waldeck; D. Branscheid; H. Magnussen; K.F. Rabe
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 78 KB
- Volume
- 361
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The mechanisms producing long duration of action for formoterol and salmeterol are not fully understood. The aim of the current study was to examine how the concentration of long and short acting beta 2-adrenoceptor agonists affects their relaxation kinetics in airway smooth muscle. Onset (time to p
ANF, ANF7-28 and atriopeptins (AP1, AP2 and AP3) (10(-11) to 3 x 10(-7) M) induce a relaxant response on the guinea-pig isolated trachea, which is partially potentiated by the enkephalinase inhibitor thiorphan 10(-5) M but is unmodified by epithelium removal. Conversely, these drugs were found to be