Effect of atrial natriuretic peptide and on atriopeptins on the human isolated bronchus. Comparison with the reactivity of the guinea-pig isolated trachea

✍ Scribed by M-L. Candenas; E. Naline; L. Puybasset; P. Devillier; C. Advenier

• Publisher: Elsevier
• Year: 1991
• Tongue: English
• Weight: 521 KB
• Volume: 4
• Category: Article
• ISSN: 0952-0600
• DOI: 10.1016/0952-0600(91)90062-8

✦ Synopsis

ANF, ANF7-28 and atriopeptins (AP1, AP2 and AP3) (10(-11) to 3 x 10(-7) M) induce a relaxant response on the guinea-pig isolated trachea, which is partially potentiated by the enkephalinase inhibitor thiorphan 10(-5) M but is unmodified by epithelium removal. Conversely, these drugs were found to be without any significant relaxant effect on the isolated human bronchus. Several hypotheses, such as the activation of ANF receptors not located on airway smooth muscle or an indirect effect of ANF in vivo are suggested to explain the discrepancy between these in vitro results and those of clinical trials in asthmatic subjects.