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The reaction of osmium tetroxide-pyridine complexes with nucleic acid components

โœ Scribed by L.R. Subbaraman; Jijie Subbaraman; E.J. Behrman

Publisher
Elsevier Science
Year
1971
Weight
890 KB
Volume
1
Category
Article
ISSN
0006-3061

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โœฆ Synopsis

Thymine and its derivatives react rapidly in aqueous solution with osmium tetroxide and pyridine to form stable bis(pyridine) osmate esters. We have studied these esters with the following pyrimidines: thymine, thymidine, thymidine-5'-phosphate, and uracil, using pyridine, 3-picoline, 3-chloropyridine, and 3-pyridyl mercuric acetate as the pyridine components. We have examined the kinetics of these reactions as a function of the concentration of substrate, pyridine, osmium tetroxide, and pH. The kinetic dependencies suggest the following rate expression:

. We report values for ~, g~, k~, and ks.

๐Ÿ“œ SIMILAR VOLUMES

On the question of phosphate complexes o
On the question of phosphate complexes of osmium tetroxide: kinetics of reactions with nucleotides and dinucleoside monophosphates
โœ Robert L. Clark; E.J. Behrman ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Elsevier Science โš– 117 KB

Konishevskaya et al. [I] observed that phosphate ions increased the rate of the reaction between hydrazine and vanadate ions catalyzed by osmium tetroxide. They claimed that phosphate ions form a 1:l complex with osmium tetroxide, & = 250 + 60. We were concerned with this report because of our inter