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The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks

✍ Scribed by Ping-Kun Zhou; Anthony R.M Sproston; Brian Marples; Catherine M.L West; Geoffrey P Margison; Jolyon H Hendry

Book ID
119521942
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
190 KB
Volume
47
Category
Article
ISSN
0167-8140

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We asked whether the constitutive level of DNA strand breaks (SBs) in four human squamous carcinoma cell lines is associated with their radiosensitivity, measured by the clonogenic assay. Because impairment in DNA replication and the action of endogenous deoxyribonucleases are two major sources of D