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Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks

✍ Scribed by El-Awady, R A; Dikomey, E; Dahm-Daphi, J

Book ID: 109997675
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 303 KB
Volume: 89
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6601133

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## Abstract Wortmannin (WM) is a potent inhibitor of the catalytic sub‐unit of DNA‐PK, which is involved in one pathway of DNA double‐strand break (DSB) rejoining, and of ATM, which functions upstream in the p53 signaling pathway. WM is known to be an efficient radiosensitizer in a variety of mamma