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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

✍ Scribed by Patrick A. Lewis; Elisa Greggio; Alexandra Beilina; Shushant Jain; Acacia Baker; Mark R. Cookson

Book ID
116294798
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
545 KB
Volume
357
Category
Article
ISSN
0006-291X

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## Abstract We report the neuropathological findings in a patient with Parkinson's disease (PD) associated with Basque R1441G‐__LRRK2__/dardarin mutation. The patient was a man with disease onset at 68 years of age, with unilateral rest tremor; the Parkinsonism was well controlled with medication f