✦ LIBER ✦

The R1441C mutation alters the folding properties of the ROC domain of LRRK2

✍ Scribed by Yongchao Li; Laura Dunn; Elisa Greggio; Brian Krumm; Graham S. Jackson; Mark R. Cookson; Patrick A. Lewis; Junpeng Deng

Book ID: 116270818
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 308 KB
Volume: 1792
Category: Article
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2009.09.010

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The R1441C mutation of LRRK2 disrupts GT

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

✍ Patrick A. Lewis; Elisa Greggio; Alexandra Beilina; Shushant Jain; Acacia Baker; 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 545 KB

Choreo-athetosis in LRRK2 R1441C mutatio

Choreo-athetosis in LRRK2 R1441C mutation: Expanding the clinical phenotype

✍ Borroni, Barbara; Cotelli, Maria Sofia; Marchina, Eleonora; Filosto, Massimilian 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 250 KB

Parkinson disease-associated mutation R1

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

✍ Liao, J.; Wu, C.-X.; Burlak, C.; Zhang, S.; Sahm, H.; Wang, M.; Zhang, Z.-Y.; Vo 📂 Article 📅 2014 🏛 National Academy of Sciences 🌐 English ⚖ 919 KB

Evidence that the LRRK2 ROC domain Parki

Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation

✍ Greene, Izabella D.; Mastaglia, Francis; Meloni, Bruno P.; West, Kristin A.; Chi 📂 Article 📅 2013 🏛 John Wiley and Sons 🌐 English ⚖ 516 KB

Neuropathology of Parkinson's disease wi

Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2

✍ José-Félix Martí-Massó; Javier Ruiz-Martínez; Maria J. Bolaño; Irune Ruiz; Ana G 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

## Abstract We report the neuropathological findings in a patient with Parkinson's disease (PD) associated with Basque R1441G‐__LRRK2__/dardarin mutation. The patient was a man with disease onset at 68 years of age, with unilateral rest tremor; the Parkinsonism was well controlled with medication f

Structure of the Roc–COR domain tandem o

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

✍ Gotthardt, Katja; Weyand, Michael; Kortholt, Arjan; Van Haastert, Peter J M; Wit 📂 Article 📅 2008 🏛 Nature Publishing Group 🌐 English ⚖ 37 KB