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The quality of DNA double-strand breaks: A Monte Carlo simulation of the end-structure of strand breaks produced by protons and alpha particles

โœ Scribed by A. Ottolenghi; M. Merzagora; L. Tallone; M. Durante; H. G. Paretzke; W. E. Wilson


Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
603 KB
Volume
34
Category
Article
ISSN
0301-634X

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A method is described for measuring the average number of nucleaseinduced single-and double-strand breaks per DNA molecule. The procedure involves measuring the weight-average molecular weight of DNase I-digested DNA under neutral and alkaline conditions. A statistical equation is used to calculate