The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects
✍ Scribed by Mohammed A. Hassan, Omar S. Al-Attas…
- Book ID
- 120748611
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 211 KB
- Volume
- 380
- Category
- Article
- ISSN
- 0300-8177
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## Abstract __Purpose__: To investigate the association of matrix metalloproteinase‐9 (MMP‐9) and paraoxonase 1 (PON1) 192 polymorphisms with susceptibility to coronary artery stenosis (CAS) and the number of diseased vessels in patients with CAS. __Methods__: The study population comprised 302 unr
## Abstract Paraoxonase 1 (PON 1) is a high‐density lipoprotein (HDL)‐associated enzyme with antioxidant function protecting low‐density lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity o