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The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity

โœ Scribed by M. Klannemark; M. Orho; D. Langin; H. Laurell; C. Holm; S. Reynisdottir; P. Arner; L. Groop


Publisher
Springer
Year
1998
Tongue
English
Weight
83 KB
Volume
41
Category
Article
ISSN
0012-186X

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Over 30 years after the original description of Randle's cycle, the mechanisms by which elevated circulating non-esterified fatty acids might be causally related to glucose intolerance in Type 2 diabetes mellitus remain uncertain. This review examines the evidence that elevated plasma NEFA can inhib