✦ LIBER ✦

Role of non-esterified fatty acids in the pathogenesis of Type 2 diabetes mellitus

✍ Scribed by Paolisso, G.; Howard, B.V.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 92 KB
Volume: 15
Category: Article
ISSN: 0742-3071
DOI: 10.1002/(sici)1096-9136(199805)15:5<360::aid-dia568>3.0.co;2-w

No coin nor oath required. For personal study only.

✦ Synopsis

Over 30 years after the original description of Randle's cycle, the mechanisms by which elevated circulating non-esterified fatty acids might be causally related to glucose intolerance in Type 2 diabetes mellitus remain uncertain. This review examines the evidence that elevated plasma NEFA can inhibit glucose-stimulated insulin secretion by pancreatic beta-cells and impair glucose-and insulin-stimulated glucose disposal by peripheral tissues. Experimental evidence beginning to examine the mechanisms of these phenomena is discussed.

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