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The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus

✍ Scribed by R. E. Pratley; C. Weyer


Publisher
Springer
Year
2001
Tongue
English
Weight
337 KB
Volume
44
Category
Article
ISSN
0012-186X

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Over 30 years after the original description of Randle's cycle, the mechanisms by which elevated circulating non-esterified fatty acids might be causally related to glucose intolerance in Type 2 diabetes mellitus remain uncertain. This review examines the evidence that elevated plasma NEFA can inhib