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The Protection of Terminal Alkynes Against Grignard Reagents by the Trimethylsilyl Group

โœ Scribed by Plavac, Nicholas; Bersohn, Malcolm


Book ID
118015833
Publisher
Taylor and Francis Group
Year
1983
Tongue
English
Weight
101 KB
Volume
13
Category
Article
ISSN
0039-7911

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Intramolecular carbometallation of grign
โœ Sadao Fujikura; Masaharu Inoue; Kiitiro Utimoto; Hitosi Nozaki ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 193 KB

Reaction of 6-bromo-l-trimethylsilyl-l-hexyne with magnesium affords the corresponding Grignard reagent whose C-Mg bond intramolecularly adds to the trimethylsilylacetylene moiety in 5-Exo-Dig manner and suprafacially. The reaction can be applied to the synthesis of some cycloalkanes having stereode