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β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group

✍ Scribed by Bruce H. Lipshutz; Joseph J. Pegram


Book ID
108380265
Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
293 KB
Volume
21
Category
Article
ISSN
0040-4039

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β-Trimethylsilylethanesulfonyl chloride
✍ Steven M Weinreb; Donald M Demko; Thomas A Lessen; James P Demers 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 181 KB

The title compound, easily prepared in two steps from vinyltrimethylsilane, is a useful reagent for the protection of primary and secondary amines as their sulfonamides, which are cleaved by fluoride ion. Sulfonamides are among the most stable of amine protecting groups.' However,