Missense mutations in the chromosome 14
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Parvoneh Poorkaj; Vikram Sharma; Leojean Anderson; Ellen Nemens; Ma Elias Alonso
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Article
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1998
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John Wiley and Sons
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English
β 156 KB
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Mutations in the presenilin genes (PS-1 and PS-2) cause early onset autosomal dominant Alzheimer's disease (AD). Eight early-onset, autopsy-documented familial AD kindreds were screened for mutations in PS-1, and seven different mutations were identified. Three of these were new mutations (G209V, A4