The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator
β Scribed by Kekule, Alexander S.; Lauer, Ulrich; Meyer, Markus; Caselmann, Wolfgang H.; Hofschneider, Peter Hans; Koshy, Rajen
- Book ID
- 109762605
- Publisher
- Nature Publishing Group
- Year
- 1990
- Tongue
- English
- Weight
- 624 KB
- Volume
- 343
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/343457a0
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Sera from 11 patients with fulminant hepatitis B were tested for antibodies to translation products of the pre-S1 and pre-S2 regions of hepatitis B virus of IgM, IgA and IgG classes, as well as of IgA1, IgA2 and SIgA, with solid-phase enzyme immunoassays using native viral polypeptides. Antibodies t
A peptide was synthesized containing the entire 55 amino acid residue sequence of the hepatitis B virus (HBV) surface antigen preS2 region (ad subtype). The unconjugated peptide was inoculated into four chimpanzees. Following multiple injections, all of the animals developed specific antipeptide ant