𝔖 Bobbio Scriptorium
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Protective effect of a synthetic peptide comprising the complete pres2 region of the hepatitis b virus surface protein

✍ Scribed by Dr. Emilio A. Emini; Vivian Larson; Ronald W. Ellis; William J. Miller; Robert J. Gerety; Patricia Conard; Victor M. Garsky; Charles A. Anderson; Jorg Eichberg; D. Rick Lee

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
461 KB
Volume
28
Category
Article
ISSN
0146-6615

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✦ Synopsis

A peptide was synthesized containing the entire 55 amino acid residue sequence of the hepatitis B virus (HBV) surface antigen preS2 region (ad subtype). The unconjugated peptide was inoculated into four chimpanzees. Following multiple injections, all of the animals developed specific antipeptide antibodies that reacted with intact surface antigen particles bearing the preS2 moiety. All four peptide-inoculated animals were found to be protected from infection after intravenous challenge with live HBV of either the ad or ay subtypes.

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