A fluorescence and CD study on the interaction of synthetic lipophilic hepatitis B virus preS(120–145) peptide analogues with phospholipid vesicles
✍ Scribed by Yolanda Cajal; Francesc Rabanal; M. Asunción Alsina; Francesca Reig
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1998
- Tongue
- English
- Weight
- 971 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
un arnphiputhic striicfiirr cornhination of@-sheet and a-helix alignedparullel to thP mc.mbrunc sirrficcc, involving the N-terminal rc~sidiies, and pcndruting onlv u short distance into (he h ~,drophohic core. Thc C-tcrminul purl. kiith u comhinufion of @-turn and @-sheet Ttriicture, remains UI thc oirter purt ofthe biluyer, being potentially accessible to immirnocompetent cells. Fiirfhermorc coiipling of an hydrophobic moiety to the N-terminal purt qflhe peptide.1uvor.y anchoring t o the mernbranc, probably facilituting interaction ofthe peptide with the i m m w oglohiilin rcccptor. T h e r ~ resiilts a r t in agreemmf Lvith the indiiction qf itnmunc responsr by p r d ( 120-145) und with the enhunced immunogenicit~i.fi,iind in general jijr lipid-conjugutd irnrnrino~~c~~~tid~~.~.