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The preparation of N-(1H-pyrazol-3-yl)arylamides and 1H-pyrazol-3-amines from polylithiated C(α),N-thiosemicarbazones and C(α),N-semicarbazones

✍ Scribed by Charles F. Beam; Sharon E. Davis; Tracy L. Cordray; Kam W. Chan; Camille M. Kassis; Joanna G. Freeman Davis; G. Mark Latham; Tina S. Guion; Karen C. Hildebran; A. Cameron Church; Madlene U. Koller; Clyde R. Metz; William T. Pennington; Kevin L. Schey

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
531 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

C(α),N‐Thiosemicarbazones or C(α),N‐semicarbazones were polylithiated with excess lithium diiso‐propylamide, and the resulting cyclized intermediates were condensed with aromatic esters to afford N‐(1__H__‐pyrazol‐3‐yl)arylamides. The polylithiated intermediates were also quenched with aqueous acid to give 5‐substituted, 1__H__‐pyrazol‐3‐amines.

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