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Preparation of 2-(1H-pyrazol-5-yl)benzenesulfonamides from polylithiated C(α),N-carbo-tert-butoxyhydrazones and methyl 2-(aminosulfonyl)benzoate

✍ Scribed by John D. Knight; Jordan B. Brown; Jason S. Overby; Charles F. Beam; N. Dwight Camper

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
408 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Select C(α), N‐carbo‐__tert‐butoxyhydrazones were dilithiated with excess lithium diisopropylamide followed by condensation with methyl 2‐(aminosulfonyl)benzoate, acid cyclization, hydrolysis, and decarboxylation to afford new 2‐(1__H‐pyrazol‐5‐yl)benzenesulfonamides, [NH‐pyrazolyl‐ortho‐benzene‐sulfonamides].

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