✍ Scribed by Bonnie J. Grant; Catherine R. Kramp; John D. Knight; Michelle A. Meierhoefer; Jarrett H. Vella; Carolyn L. Sober; Stephen S. Jones; Clyde R. Metz; Charles F. Beam; William T. Pennington; Donald G. Vanderveer; N. Dwight Camper
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Several dilithiated C(α), O‐oximes were prepared in excess lithium diisopropylamide‐tetramethyl‐ethylenediamine (LDA/TMEDA) and condensed with methyl 2‐(aminosulfonyl)benzoate followed by acid cyclization of intermediates to spiro(benzoisothiazole‐isoxazole) dioxides, a new spiro and fused‐ring system. Distortionless enhancement by polarization transfer (DEPT) and liquid chromatography mass spectrometry (LCMS) for all products, as well as X‐ray single crystal analysis on a representative product, were especially relevant for structure confirmation in this synthesis.
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## Abstract magnified image A variety of substituted spiro(benzoisothiazole‐pyrazoles) have been prepared by the condensation of dilithiated __C__(α),__N__‐carboalkoxyhydrazones with lithiated methyl 2‐(aminosulfonyl)benzoate followed by the cyclization of intermediates with acetic anhydride, whic
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## Abstract Select dilithiated __ortho__‐toluic acids were prepared in excess lithium diisopropylamide and condensed with methyl 2‐(aminosulfonyl)benzoate followed by a twofold cyclization of intermediates to afford benzoisothiazolo[1,2‐__b__][1,2]isoquinolin‐11‐one‐1,1‐dioxides, a new fused‐ring h