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The preparation of benzoisothiazolo[1,2-b][1,2]isoquinolin-11-one-1,1-dioxides from dilithiated ortho-toluic acids and lithiated methyl 2-(aminosulfonyl)benzoate

✍ Scribed by S. Patrick Dunn; Matthew J. Walters; Clyde R. Metz; Charles F. Beam; William T. Pennington; Mariusz Krawiec

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
68 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Select dilithiated ortho‐toluic acids were prepared in excess lithium diisopropylamide and condensed with methyl 2‐(aminosulfonyl)benzoate followed by a twofold cyclization of intermediates to afford benzoisothiazolo[1,2‐b][1,2]isoquinolin‐11‐one‐1,1‐dioxides, a new fused‐ring heterocyclic system.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

The preparation of 3-substituted 1,2-ben
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Several β-ketoesters were dilithiated with an excess of lithium diisopropylamide, followed by condensation with methyl 2-(aminosulfonyl)benzoate to give intermediates that were not isolated but cyclized to 3substituted 1,2-benzisothiazole-1,1-dioxides. In most instances involving the ester-sulfonami

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