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The preparation of 3-substituted 1,2-benzisothiazole 1,1-dioxides from lithiated intermediates or grignard reagents and methyl 2-(aminosulfonyl)benzoate

✍ Scribed by S. Patrick Dunn; Laela M. Hajiaghamohseni; Sara B. Lioi; Michelle A. Meierhoefer; Matthew J. Walters; Charles F. Beam

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
131 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A polylithiated β‐ketoester, β‐diketone, or β‐ketoamide was condensed‐cyclized with lithiated methyl 2‐(aminosulfonyl)benzoate, to afford new 3‐substituted 1,2‐benzisothiazole 1,1‐dioxides. Some Grignard or organolithium reagents were also condensed‐cyclized with methyl 2‐(aminosulfonyl)benzoate to give 3‐substituted 1,2‐benzisothiazole 1,1‐dioxides.

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The Preparation of 3-Substituted 1,2-Ben
The Preparation of 3-Substituted 1,2-Benzisothiazole-1,1-dioxides from the Condensation—Cyclization of Dilithiated β-Ketoesters with Methyl 2-(Aminosulfonyl)benzoate or 1,2-Benzisothiazol-3(2H)-one-1,1-dioxide.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

The preparation of 3-substituted 1,2-ben
The preparation of 3-substituted 1,2-benzisothiazole-1,1-dioxides from the condensation-cyclization of dilithiated β-ketoesters with methyl 2-(aminosulfonyl)benzoate or 1,2-benzisothiazol-3(2H)-one-1,1-dioxide
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