## Abstract Utilizing sodium [1β^14^C]propionate as a precursor, [^14^C]FKβ506, labeled at carbon atoms 10, 16, 18, 21a, 24, and 26, was produced by fermentative biosynthesis. Extractive isolation followed by chromatographic purification provided material of purity suitable for metabolism studies.
The preparation of C14-labeled tetramethylammonium bromide
β Scribed by A.F. Smetana; J. Haberman; T.C. Castorina
- Publisher
- Elsevier Science
- Year
- 1964
- Weight
- 424 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0020-708X
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## Abstract [2β^14^C]Pyridostigmine bromide was prepared in 17.6% radiochemical yield with specific activity of 18 mCi/mmol. The reaction sequence involved preparation of 2βfuran[^14^C]carboxylic acid by carbonation of 2βlithiofuran, followed by conversion to 2βamino[^14^C]methyl furan by lithium a
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