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The preparation of 5′-iodo-125I-Δ8-THC; a radioligand for the radioimmunoassay of cannabinoids

✍ Scribed by Colin G. Pitt; Herbert H. Seltzman; Susan R. Setzer; David L. Williams

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
306 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Nucleophilic exchange of 5′‐iodo‐Δ^8^‐THC and sodium iodide‐125 afforded 5′‐iodo‐^125^I‐Δ^8^THC with a maximum specific activity of 42 Ci/mmole. The specific activity could be increased to at least 100 Ci/mmole by iodide‐125 displacement of the corresponding 5′‐tosylate. A hapten 5′‐carboxy‐^14^C‐Δ^9^‐THC, for use in conjunction with this radioligand, was synthesized from 5′‐bromo‐Δ^8^‐THC.

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