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The preparation of 2,4-disubstituted thiazoles on solid support

✍ Scribed by Dane Goff; Juan Fernandez


Book ID
104260420
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
189 KB
Volume
40
Category
Article
ISSN
0040-4039

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3-Iodobenzoic acid was loaded on Rink amide resin. Pd(0) coupling reaction with tributyl(1-ethoxyvinyl)tin followed by bromination using NBS gave an a-bromoketone bound to a solid support. Condensation of thioamide or thiourea, followed by TFA cleavage from the resin, gave 2,4-disubstituted thiazole

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