3-Iodobenzoic acid was loaded on Rink amide resin. Pd(0) coupling reaction with tributyl(1-ethoxyvinyl)tin followed by bromination using NBS gave an a-bromoketone bound to a solid support. Condensation of thioamide or thiourea, followed by TFA cleavage from the resin, gave 2,4-disubstituted thiazole
The preparation of 2,4-disubstituted thiazoles on solid support
β Scribed by Dane Goff; Juan Fernandez
- Book ID
- 104260420
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 189 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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