The Preparation of [15N,15N']-and [4,4'-13 C2]-4,4'-Dichloroazobenzene and [ , Nt]-4-Chloroazobenzene 15N 15
The preparation of 15N-phenoxybenzamine
✍ Scribed by W. L. Mendelson; L. E. Weaner; L. A. Petka; D. W. Blackburn
- Book ID
- 102370495
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- French
- Weight
- 164 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Phenoxybenzamine [N‐Bethyl‐N‐(l‐phenoxyisopropyl)‐2‐chloroethylamine hydrochloride] has been labelled with Nitrogen‐15 by a direct synthesis from ^15^N‐ammonium chloride. The isotopic enrichment was 92.8%.
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## Abstract The precursor for the title compound was prepared in a three‐step synthesis. The ^13^C‐label was incorporated in the first step employing 2‐^13^C‐ethyl acetate and the ^15^N‐label in the last step, using ^15^N‐sodium nitrite. Upon pyrolysis the precursor forms three fragments, one of th
## Abstract ^15^N labeled tetranitromethane, C(^15^NO~2~)~4~, was prepared from anhydrous nitric acid and acetic anhydride. A procedure for the preparation of the nitric acid from Na^15^NO~3~ is described. Tyrosine was nitrated with H^15^NO~3~ and its ^15^N NMR spectrum compared well with that of t