## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐
The Preparation and Evaluation of 1-Substituted 1,2,3,4-Tetrahydro- and 3,4-Dihydro-β-carboline Derivatives as Potential Antitumor Agents.
✍ Scribed by Ya-Ching Shen; Ching-Yeu Chen; Pei-Wen Hsieh; Chang-Yih Duh; Yat-Min Lin; Chin-Lien Ko
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 16 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
For Abstract see ChemInform Abstract in Full Text.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A series of 4β‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin analogues have been synthesized with high regio‐selectivity by employing copper(I)‐catalyzed 1,3‐dipolar cycloaddition of 1‐__O__‐propargyl monosaccharides with C4β‐azido podophyllotoxin and C4β‐azido‐4′‐__O__‐demethyl p