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ChemInform Abstract: Antitumor Agents. Part 181. Synthesis and Biological Evaluation of 6,7,2′,3′,4′-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents.

✍ Scribed by Y. XIA; Z.-Y. YANG; P. XIA; K. F. BASTOW; Y. TACHIBANA; S.-C. KUO; E. HAMEL; T. HACKL; K.-H. LEE

Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Antitumor Agents. Part 181. Synthesis and Biological Evaluation of 6,7,2',3',4'-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents.

-Some of the most active compounds are (IVd) and (VI) showing strong cytotoxic effects with very low ED 50 . Three active racemates, e.g. (IVc), are separated into the enantiomers. The (-)-enantiomers exhibit greater biological activity than the racemates or (+)-isomers.

-(XIA, Y.; YANG, Z.-Y.;

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