## Abstract Electrochemical deoxygenation of methyl 7βketoβlithocholate using deuterated reagents, followed by base hydrolysis is shown to give [7,7β^2^H~2~] lithocholic acid in 60% overall yield and 86% ^2^H~2~ isotopic purity.
β¦ LIBER β¦
The Preparation and Degradation of Lithocholic Acid
β Scribed by Hoehn, Willard M.; Mason, Harold L.
- Book ID
- 126083359
- Publisher
- American Chemical Society
- Year
- 1940
- Tongue
- English
- Weight
- 230 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
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## Abstract A convenient synthesis is reported of lithocholic acid labelled in high isotopic purity with two atoms of deuterium at Cβ11. Incorporation of deuterium is achieved by baseβcatalyzed equilibration of a 12βoxo bile acid in heavy water. The product is converted __in situ__ into its tosylhy