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The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike–wave discharges in the WAG/Rij rat model of absence epilepsy

✍ Scribed by R.T. Ngomba; F. Biagioni; S. Casciato; E. Willems-van Bree; G. Battaglia; V. Bruno; F. Nicoletti; E.L.J.M. van Luijtelaar


Book ID
116784393
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
667 KB
Volume
49
Category
Article
ISSN
0028-3908

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CNQX, a new non-NMDA receptor antagonist
✍ G.M.J. Ramakers; B.W.M.M. Peeters; J.M.H. Vossen; A.M.L. Coenen 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 330 KB

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik